The main square of the city is named after Girolamo Fabrici d’Acquapendente, born here in 1533 from a noble family. At the age of 17 he moved to Padua to study medicine and became a great anatomist. Tito Sarrocchi immortalizes him in a splendid statue placed in the center of the square where he shows him with his head slightly inclined forward almost as if he had been caught in the act of explaining his discoveries, in one hand he wields his knives as a surgeon, with the other he is leaning against a pedestal on which his books are placed. The Town Hall was founded in the decades that followed the unity of Italy in the area where the old palace was located, and is an imposing work done in neoclassical style designed by Guglielmo Meluzzi.

On the square there are some buildings dating back to the sixteenth century, adorned with portals in basaltina: Petrucci-Piccioni palace, Benci-Caterini palace and Savini-Costantini palace, respectively in front, on the right and on the left of the Town Hall.

Piazza G. Fabrizio, together with the contiguous Piazza G. Oberdan, the Taurelli Salimbeni avenue, Piazza N. Sauro and the two small squares of the Rigombo and the Rugarella springs, outline a sequence of spaces that defines an original and elegant urban design.